Pair Name	Parthenolide, Temozolomide
Disease Info	[ICD-11: 2F7Z]	Glioma		Investigative
Gene Regulation	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Down-regulation	Expression	MGMT	hsa4255
	Down-regulation	Activity	NFKB1	hsa4790
	Up-regulation	Cleavage	PARP1	hsa142
In Vitro Model	T98G	Glioblastoma	Homo sapiens (Human)	CVCL_0556
	LN-18	Glioblastoma	Homo sapiens (Human)	CVCL_0392
Result	These findings suggest that NF-κB is a potential target for inducing cell death in gliomas. A targeted combination strategy in which the response to TMZ is synergistically enhanced by the addition of parthenolide which may be useful, especially in chemoresistant gliomas with high MGMT expression.